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Case Reports
. 1998 Oct;7(5):415-6.
doi: 10.1016/s1059-1311(05)80013-5.

Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin

M Zadra  1 , R Grandi, L C Erli, D Mirabile, A Brambilla
Affiliations
Free article
Case Reports

Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin

M Zadra et al. Seizure. 1998 Oct.
Free article

Abstract

Treatment of seizures in acute intermittent porphyria represents a therapeutic dilemma. Patients needing chronic therapy often experience acute porphyric attacks due to increased hepatic metabolism induced by the antiepileptic drugs themselves. Gabapentin is a new antiepileptic drug not appreciably metabolized by the liver in humans, and it appears to be safe and effective in the maintenance therapy of epilepsy in these patients. We report a patient affected by partial and generalized seizures in the course of acute intermittent porphyria, who was safely and successfully treated with gabapentin.

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