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Case Reports
. 1998 Oct;7(5):419-20.
doi: 10.1016/s1059-1311(05)80015-9.

Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (SIADH)

R Kloster  1 , H C Børresen, P Hoff-Olsen
Affiliations
Free article
Case Reports

Sudden death in two patients with epilepsy and the syndrome of inappropriate antidiuretic hormone secretion (SIADH)

R Kloster et al. Seizure. 1998 Oct.
Free article

Abstract

We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for SIADH in patients on carbamazepine and oxcarbazepine, and in cases of sudden death in epilepsy, is recommended.

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