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Review
. 1998 Oct;23(10):394-8.
doi: 10.1016/s0968-0004(98)01284-5.

DNA end-joining: from yeast to man

S E Critchlow  1 , S P Jackson
Affiliations
Review

DNA end-joining: from yeast to man

S E Critchlow et al. Trends Biochem Sci. 1998 Oct.

Abstract

DNA non-homologous end-joining (NHEJ) is a crucial process that has been conserved highly throughout eukaryotic evolution. At its heart is a multiprotein complex containing the KU70-KU80 heterodimer. Recent work has identified additional proteins involved in this pathway, providing insights into the mechanism of NHEJ and revealing exciting links with the control of transcription, telomere length and chromatin structure.

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