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Case Reports
. 1998 Oct;13(5):548-50.
doi: 10.3346/jkms.1998.13.5.548.

Acute hemolytic crisis with fulminant hepatic failure as the first manifestation of Wilson's disease: a case report

J J Lee  1 , H J Kim, I J Chung, H Kook, J R Byun, S Y Kwon, M R Park, K S Choi, T J Hwang, D W Ryang
Affiliations
Case Reports

Acute hemolytic crisis with fulminant hepatic failure as the first manifestation of Wilson's disease: a case report

J J Lee et al. J Korean Med Sci. 1998 Oct.

Abstract

We report a 27-year-old woman who developed Coombs' negative hemolytic anemia and fulminant hepatic failure as the initial manifestation of Wilson's disease. Unmeasurably low level of serum alkaline phosphatase provided a clue to the diagnosis of Wilson's disease. The diagnosis was established with the presence of Kayser-Fleischer ring, decreased serum ceruloplasmin level, and elevated urine and serum copper levels. In spite of repeated plasmapheresis, she died of multiorgan failure on the fifth hospital day.

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