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. 1998 Nov 10;95(23):13355-7.
doi: 10.1073/pnas.95.23.13355.

DSHP: a "power bar" for sustained immune responses?

A B Satterthwaite  1 , D J Rawlings, O N Witte
Affiliations

DSHP: a "power bar" for sustained immune responses?

A B Satterthwaite et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Model for the role of DSHP in the CTL response to EBV. (A) EBV-infected B cells secrete hIL-10 and vIL-10. These cytokines augment proliferation and survival of infected B cells, up-regulate the inhibitory receptor KIR on CTLs, and act on macrophages to inhibit T and NK cell function (not shown). During the CTL response to EBV in normal individuals, DSHP (green) attenuates inhibitory signals (red) from SHIP, CTLA-4, and/or KIR late in the immune response. This prolongs the response, allowing rapidly proliferating EBV-infected cells to be controlled. (B) In XLP patients, inhibitory signals (red) predominate in the absence of DSHP, and EBV-infected B cells escape immune surveillance.
See this image and copyright information in PMC

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References

    1. Fischer A, Cavazzana-Calvo M, De Saint Basile G, DeVillartay J P, Di Santo J P, Hivroz C, Rieux-Laucat F, Le Deist F. Annu Rev Immunol. 1997;15:93–124. - PubMed
    1. Nichols K E, Harkin D P, Levitz S, Krainer M, Kolquist K A, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, et al. Proc Natl Acad Sci USA. 1998;95:13765–13770. - PMC - PubMed
    1. Purtilo D T. Springer Semin Immunopathol. 1991;13:181–197. - PubMed
    1. Seemayer T A, Gross T G, Egeler R M, Pirruccello S J, Davis J R, Kelly C M, Okano M, Lanyi A, Sumegi J. Pediatr Res. 1995;38:471–478. - PubMed
    1. Conley M E, Sullivan J L, Neidich J A, Puck J M. Clin Immunol Immunopathol. 1990;55:486–491. - PubMed

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