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Clinical Trial
. 1998 Nov;155(11):1608-10.
doi: 10.1176/ajp.155.11.1608.

Transcranial magnetic stimulation in mania: a controlled study

N Grisaru  1 , B Chudakov, Y Yaroslavsky, R H Belmaker
Affiliations
Clinical Trial

Transcranial magnetic stimulation in mania: a controlled study

N Grisaru et al. Am J Psychiatry. 1998 Nov.

Abstract

Objective: Left prefrontal transcranial magnetic stimulation has been reported to have ECT-like effects in depression; therefore, the authors planned a study of transcranial magnetic stimulation in mania.

Method: Sixteen patients completed a 14-day double-blind, controlled trial of right versus left prefrontal transcranial magnetic stimulation at 20 Hz (2-second duration per train, 20 trains/day for 10 treatment days). Mania was evaluated with the Mania Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impression.

Results: Significantly more improvement was observed in patients treated with right than with left prefrontal transcranial magnetic stimulation.

Conclusions: The therapeutic effect of transcranial magnetic stimulation in mania may show laterality opposite to its effect in depression.

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