Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Nov 9;810(1-2):257-63.
doi: 10.1016/s0006-8993(98)00880-4.

alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices

M Alkondon  1 , E F Pereira, E X Albuquerque
Affiliations

alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices

M Alkondon et al. Brain Res. .

Abstract

This study demonstrates for the first time that alpha7 nicotinic receptors (nAChRs) mediate fast synaptic transmission in conventional hippocampal slices. In the presence of antagonists of muscarinic, AMPA, NMDA, GABAA, ATP, and 5-HT3 receptors, spontaneous and evoked postsynaptic currents (PSCs) recorded from CA1 interneurons were blocked by the alpha7 nAChR antagonists methyllycaconitine and alpha-bungarotoxin and by a desensitizing concentration of the alpha7 nAChR agonist choline. Spontaneous nicotinic PSCs were also accompanied by Na+ transients, indicating that alpha7 nAChR-mediated transmission serves as an excitatory signal to the CA1 interneurons in the hippocampus.

PubMed Disclaimer

Publication types

LinkOut - more resources