Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Nov 12;194(4266):735-7.
doi: 10.1126/science.982041.

Antiserum to brain gangliosides produces recurrent epileptiform activity

S E Karpiak, L Graf, M M Rapport

Antiserum to brain gangliosides produces recurrent epileptiform activity

S E Karpiak et al. Science. .

Abstract

A single injection of 10 microliters of antiserum to total brain ganglioside onto (and into) the sensorimotor cortex of the rat resulted in recurrent spiking in the cortical electroencephalogram, lasting from 7 to 17 days. Absorption of antibody with pure monosialoganglioside (GM1) completely abosished the effect. Spiking was reactivated after 4 weeks by intramuscular injection of pentylenetetrazole.

PubMed Disclaimer

Publication types

LinkOut - more resources