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. 1976 Nov 26;194(4268):967-8.
doi: 10.1126/science.982058.

Nitrous oxide "analgesia": resemblance to opiate action

B A Berkowitz, S H Ngai, A D Finck

Nitrous oxide "analgesia": resemblance to opiate action

B A Berkowitz et al. Science. .

Abstract

Nitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.

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