Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Nov;114(2):210-4.
doi: 10.1046/j.1365-2249.1998.00698.x.

Chemokine profiles in the cerebrospinal fluid (CSF) during the course of pyogenic and tuberculous meningitis

C M Mastroianni  1 , L Lancella, F Mengoni, M Lichtner, P Santopadre, C D'Agostino, F Ticca, V Vullo
Affiliations

Chemokine profiles in the cerebrospinal fluid (CSF) during the course of pyogenic and tuberculous meningitis

C M Mastroianni et al. Clin Exp Immunol. 1998 Nov.

Abstract

The concentrations of the chemokines IL-8, monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) were measured in 120 CSF samples from 23 patients with pyogenic meningitis and from 11 patients with tuberculous meningitis (TBM) and in 10 CSF from subjects with non-infectious neurological diseases. The chemokine concentrations in patients with meningitis were significantly higher than in control subjects (P<0.0001). The highest CSF levels were found for IL-8 (median 2917 pg/ml) and MCP-1 (median 2557 pg/ml), whereas those of MIP-1alpha were less significantly elevated (median 24 pg/ml) (P<0.0001). Patients with pyogenic meningitis had higher levels of IL-8 and MCP-1 than those with TBM (P<0.0001). In serial samples from patients with pyogenic meningitis IL-8 levels declined before MCP-1 and MIP-alpha. In the case of TBM, IL-8, MCP-1 and MIP-1alpha decreased more gradually during treatment and were detectable in the CSF for several weeks, without any characteristic time course of elimination. These data indicate that patients with pyogenic meningitis and TBM show different chemokine profiles in CSF. The distinct chemokine pattern could be responsible for a differential attraction and activation of leucocytes in the CSF which is reflected in differences in the inflammatory response and clinical course of pyogenic meningitis and TBM.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
CSF concentrations of IL-8, monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1α (MIP-1α) in 34 patients at the onset of bacterial meningitis (▵) and 10 subjects with non-infectious neurological diseases (▴). Solid lines, detection limit of each chemokine.
Fig. 2
Fig. 2
Time course of chemokine levels in the CSF of patients with pyogenic meningitis (a) and tuberculous meningitis (TBM) (b). Data are expressed as median. The number of patients' samples at each time point was 23, 23, 15 and 10 for pyogenic meningitis; 11, 11, 9, 6, 6 and 6 for TBM.
See this image and copyright information in PMC

References

    1. Quagliarello V, Scheld WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med. 1992;327:964–72. - PubMed
    1. Saukkonen K, Sande S, Cioffe C, Wolpe S, Sherry B, Cerami A, Tuomanen E. The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med. 1990;171:439–48. - PMC - PubMed
    1. van Furth AM, Roord JJ, van Furth R. Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy. Infect Immun. 1996;64:4883–90. - PMC - PubMed
    1. Springer TA. Traffical signals for lymphocyte recirculation and leucocyte emigration: the multistep paradigm. Cell. 1994;76:301–14. - PubMed
    1. Oppenheim JJ, Zachariae COC, Mukaida N, Matushima K. Properties of the novel proinflammatory supergene ‘intercrine’ cytokine family. Annu Rev Immunol. 1991;9:617–48. - PubMed

Publication types