Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 1998 Dec 15;513 ( Pt 3)(Pt 3):629-30.
doi: 10.1111/j.1469-7793.1998.629ba.x.

Cross-talk between apparently independent receptors

T J Searl  1 , E M Silinsky
Affiliations
Comment

Cross-talk between apparently independent receptors

T J Searl et al. J Physiol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Three mechanisms by which non-additivity between nicotinic and P2X ATP receptors could take place
As depicted, mechanisms A–C represent decreasing membrane intimacy between the two types of receptors. In A, the receptors are closely associated and the opening of one receptor inhibits the opening of the other. Whilst the model is depicted as separate channels, it is also possible that both types of receptors are arranged around a common pore (see e.g. Nakazawa et al. 1991). In B, inward current through one receptor inhibits either the opening or the passage of current through the other nearby receptor. In C, the receptors are not in close proximity but the ATP receptor contains an inhibitory nicotinic binding site and/or the nicotinic receptor contains an inhibitory ATP binding site. For the sake of simplicity, in models A and B we show activation of the nicotinic channels occluding the ATP response. The converse may be equally true, however.
See this image and copyright information in PMC

Comment on

References

    1. Barajas-López C, Espinosa-Luna R, Zhu Y. The Journal of Physiology. 1998;513:671–683. - PMC - PubMed
    1. Kienker PK, Degrado WF, Lear JD. Proceedings of the National Academy of Sciences of the USA. 1994;91:4859–4863. - PMC - PubMed
    1. Nakazawa K, Fujimori K, Takanaka A, Inoue K. The Journal of Physiology. 1991;434:647–660. - PMC - PubMed
    1. Nakazawa K, Ito K, Koizumi S, Ohno Y, Inoue K. Life Sciences. 1995;57:351–356. - PubMed
    1. Searl TJ, Redman RS, Silinsky EM. The Journal of Physiology. 1998;510:783–791. - PMC - PubMed

MeSH terms

LinkOut - more resources