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. 1998 Oct;51(4):333-6.
doi: 10.1016/s0306-9877(98)90058-5.

The therapeutic potential of oral creatine supplementation in muscle disease

M Wyss  1 , S Felber, D Skladal, A Koller, C Kremser, W Sperl
Affiliations

The therapeutic potential of oral creatine supplementation in muscle disease

M Wyss et al. Med Hypotheses. 1998 Oct.

Abstract

The decrease in intracellular creatine concentration observed in a number of muscle diseases may deplete energy homeostasis and may, therefore, be one of the factors determining and/or aggravating muscle weakness and degeneration. Two hypotheses are put forward in the present communication to explain: (i) the mechanisms leading to the disturbances in creatine metabolism found in various muscle diseases; and (ii) the potential of oral creatine supplementation in alleviating the clinical symptoms.

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