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. 1998 Oct;18(10):1086-90.

Schwangerschafts protein 1 (SP1) adds little to the age-related detection of fetal Down syndrome in the first trimester of pregnancy

L H Kornman  1 , L P Morssink, K A Ten Hoor, B T De Wolf, M D Kloosterman, J R Beekhuis, A Mantingh
Affiliations
  • PMID: 9826903

Schwangerschafts protein 1 (SP1) adds little to the age-related detection of fetal Down syndrome in the first trimester of pregnancy

L H Kornman et al. Prenat Diagn. 1998 Oct.

Abstract

Schwangerschafts Protein 1 (SP1), being a placental protein appearing in the maternal circulation early in pregnancy, has been investigated as a potential marker for Down syndrome in the first trimester. Our study compared SP1 levels in 15 pregnancies with a Down syndrome fetus and 97 matched controls. Although the median MoM in Down syndrome pregnancies (0.49) was lower than in controls, its use as a marker added very little to the detection rate above the maternal age alone.

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