doi: 10.1101/sqb.1978.042.01.094.
Organization of immunoglobulin genes
- PMID: 98276
- DOI: 10.1101/sqb.1978.042.01.094
Item in Clipboard
Organization of immunoglobulin genes
Cold Spring Harb Symp Quant Biol.
1978.
Abstract
The nucleotide-sequence determination of a cloned, embryonic Vlambda gene directly demonstrated that V genes are separate from a corresponding C gene in embryonic cells. Analysis by restriction enzymes of total cellular DNA from various sources strongly suggested that the two separate immunoglobulin genes become continuous during differentiation of B lymphocytes. There seems to be a strict correlation between the joining event and activation of the joined genes. Cloning of more immunoglobulin genes from embryo and plasma cells will not only provide direct demonstration of such a gene-joining event but also help in the elucidation of a possible relationship of the event to gene activation mechanisms.
Similar articles
-
A complete immunoglobulin gene is created by somatic recombination.Cell. 1978 Sep;15(1):1-14. doi: 10.1016/0092-8674(78)90078-8. Cell. 1978. PMID: 100225
-
Organization of four mouse lambda light chain immunoglobulin genes.Proc Natl Acad Sci U S A. 1981 Jun;78(6):3765-9. doi: 10.1073/pnas.78.6.3765. Proc Natl Acad Sci U S A. 1981. PMID: 6791160 Free PMC article.
-
Immunoglobulin genes.Mol Immunol. 1980 Nov;17(11):1423-35. doi: 10.1016/0161-5890(80)90012-7. Mol Immunol. 1980. PMID: 6780788 Review. No abstract available.
-
[Genetics of immunoglobulins].Zh Mikrobiol Epidemiol Immunobiol. 1980 May;(5):34-40. Zh Mikrobiol Epidemiol Immunobiol. 1980. PMID: 6251679 Russian. No abstract available.
-
Organization and expression of murine immunoglobulin genes.Immunol Rev. 1981;59:5-32. doi: 10.1111/j.1600-065x.1981.tb00454.x. Immunol Rev. 1981. PMID: 6273295 Review. No abstract available.
Cited by
-
The discovery of agammaglobulinaemia in 1952.Eur J Pediatr. 2003 May;162(5):289-304. doi: 10.1007/s00431-003-1153-7. Epub 2003 Mar 1. Eur J Pediatr. 2003. PMID: 12692709
-
Detection and location of three simple sequence DNAs in polytene chromosomes from virilis group species of Drosophila.Chromosoma. 1979 Aug;73(3):327-55. doi: 10.1007/BF00288696. Chromosoma. 1979. PMID: 510073
-
Chemical carcinogenesis -- the price for DNA - repair?Naturwissenschaften. 1982 Mar;69(3):107-13. doi: 10.1007/BF00376714. Naturwissenschaften. 1982. PMID: 7043281 Review.
-
Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.Proc Natl Acad Sci U S A. 1981 Jan;78(1):616-20. doi: 10.1073/pnas.78.1.616. Proc Natl Acad Sci U S A. 1981. PMID: 6165999 Free PMC article.
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
