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Clinical Trial
. 1998 Sep;79(2):F110-3.
doi: 10.1136/fn.79.2.f110.

Randomised controlled trial of cisapride in feed intolerance in preterm infants

A Enriquez  1 , S Bolisetty, S Patole, P A Garvey, P J Campbell
Affiliations
Clinical Trial

Randomised controlled trial of cisapride in feed intolerance in preterm infants

A Enriquez et al. Arch Dis Child Fetal Neonatal Ed. 1998 Sep.

Abstract

Aim: To assess the efficacy of cisapride in reducing the time required to establish enteral feeds in preterm infants.

Methods: A randomised, double blind, placebo controlled trial was conducted of 34 infants of < or = 32 weeks of gestation, assigned to receive either cisapride 0.2 mg/kg/dose four times daily (n = 18) or placebo (n = 16).

Results: The time taken by the babies to tolerate full enteral feeds was not significantly different between the groups (median 9.5 days vs 10 days). There was a significantly lower incidence of large gastric residuals and regurgitation in the treated group compared with the placebo group. The number of episodes of large gastric residuals per infant was also significantly less. No adverse effects were noted.

Conclusion: The routine use of cisapride in preterm infants cannot be recommended to decrease the time to establish enteral feeds. Its use may be justified for clinically significant gastric stasis or regurgitation.

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Comment in

  • Role of cisapride in preterm infants.
    Craig JS, McClure BG, Tubman TR. Craig JS, et al. Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F253. doi: 10.1136/fn.80.3.f252d. Arch Dis Child Fetal Neonatal Ed. 1999. PMID: 10744431 Free PMC article. No abstract available.
  • The use of cisapride in neonates.
    Davies MW. Davies MW. Arch Dis Child Fetal Neonatal Ed. 2000 Jul;83(1):F75. doi: 10.1136/fn.83.1.f74c. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 10917723 Free PMC article. No abstract available.

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