Differential diagnosis of lymph node lesions: a semiquantitative approach with colour Doppler ultrasound

Abstract

The aim of this study was to evaluate reactively enlarged cervical lymph nodes and nodal metastases in patients with squamous cell carcinoma, as well as nodes involved by malignant lymphoma, by means of colour Doppler ultrasound (CDUS) and to describe perfusion sites for each nodal group in order to determine if typical flow patterns exist for nodes with different pathology. In a prospective study, 63 untreated patients with palpable cervical lymph node enlargement (n = 208) underwent examination with CDUS. The sites of perfusion were subdivided into three groups: central, peripheral and hilar perfusion. The intensity of perfusion was subjectively quantified in a semiquantitative scale from 0 (no perfusion) to III (high perfusion). Finally, the overall perfused area of the lymph nodes was measured and the percentage of perfused nodal area was calculated. CDUS showed perfusion in 178 of 208 lymph nodes. Histological examination showed 49 reactively enlarged lymph nodes, 82 containing metastases and 47 with lymphoma. Reactively enlarged lymph nodes showed characteristically intense hilar perfusion (91.8%), whereas nodal metastases had mainly peripherally located flow (84.1%) of intensity grades I-III. Lymph nodes invaded by malignant lymphoma were highly perfused, showing colour signals in the centre as well as in the nodal periphery (78.7%). In conclusion, perfusional patterns may provide useful additional information in the differential diagnosis of cervical lymphadenopathy.