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. 1998 Aug;51(8):593-6.
doi: 10.1136/jcp.51.8.593.

Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer

D C Fang  1 , J R Jass, D X Wang
Affiliations

Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer

D C Fang et al. J Clin Pathol. 1998 Aug.

Abstract

Aim: To investigate the role of DCC gene inactivation in the development and progression of gastric cancer.

Methods: Loss of heterozygosity and loss of expression of the DCC gene was studied in 51 surgical specimens of gastric cancer using detection based on polymerase chain reaction.

Results: Loss of heterozygosity was found in 35.3% (18 of 51) of specimens and was detected more often in stage III and IV (50%) than in stage I and II cancers (14.3%) (p < 0.05). Occurrence of loss of heterozygosity was not correlated with histological type, tumour size, depth of invasion, or lymph node metastasis. Loss of expression was found in 49% of cases (25 of 51). Loss of expression was not significantly correlated with any clinicopathological variable.

Conclusions: Loss of heterozygosity and loss of expression of the DCC gene are often encountered in gastric cancer. Loss of heterozygosity of the DCC gene is a late event and associated with malignant progression.

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