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Case Reports
. 1998 Aug;51(8):602-5.
doi: 10.1136/jcp.51.8.602.

Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear

S Y Leung  1 , S T Yuen, C M Ho, W K Kwong, L P Chung
Affiliations
Case Reports

Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear

S Y Leung et al. J Clin Pathol. 1998 Aug.

Abstract

Aim: To examine the association of Epstein-Barr virus (EBV) with carcinoma of the ear.

Methods: Five non-keratinising squamous cell carcinomas and two undifferentiated carcinomas of the ear were examined. In situ hybridisation was used to localised EBV-encoded RNAs (EBER). Immunohistochemical methods to detect LMP-1 and EBNA2 were performed in the EBER positive cases.

Results: Two cases were EBER positive, including one non-keratinising and one undifferentiated carcinoma. Both showed identical morphology to those arising from the nasopharynx, with abundant lymphoid stroma. They were both negative for LMP-1 and EBNA2.

Conclusions: EBV associated carcinoma with the morphology of lymphoepithelioma can also arise from the middle ear.

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