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. 1998 Sep;57(1):21-6.
doi: 10.1016/s0168-1702(98)00079-3.

Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate

V Gouvea  1 , N Snellings, M J Popek, C F Longer, B L Innis
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Hepatitis E virus: complete genome sequence and phylogenetic analysis of a Nepali isolate

V Gouvea et al. Virus Res. 1998 Sep.

Abstract

The complete nucleotide sequence of the Nepali strain TK15/92 of hepatitis E (HEV) was determined. It showed the highest sequence homology with the Burmese B1 strain, but closer evolutionary relatedness to the Indian strains. Difficulties in reverse-transcribing and amplifying the hypervariable region in ORF1 suggested that strong secondary structures might be intrinsically responsible for the high mutational rate observed in this region of the HEV genome.

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