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. 1998 Dec;42(12):3320-4.
doi: 10.1128/AAC.42.12.3320.

In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria

A Giacometti  1 , O Cirioni, G Greganti, M Quarta, G Scalise
Affiliations

In vitro activities of membrane-active peptides against gram-positive and gram-negative aerobic bacteria

A Giacometti et al. Antimicrob Agents Chemother. 1998 Dec.

Abstract

Four peptides, cecropin P1, magainin II, indolicidin, and ranalexin, were evaluated against 202 clinical isolates of gram-positive and gram-negative aerobic bacteria by a microbroth dilution method. The gram-negative isolates were more susceptible to cecropin P1. Ranalexin was the most active compound against the gram-positive strains. The bactericidal activity of each peptide was equivalent to, or 1 dilution above, the MIC. In conclusion, the four peptides exhibited different in vitro activities and rapid time-dependent killing.

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Figures

FIG. 1
FIG. 1
Time-kill kinetics of membrane-active peptides against S. aureus ATCC 25923 (a) and E. coli ATCC 25922 (b). Peptides were tested at a concentration of 32 μg/ml.
See this image and copyright information in PMC

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