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Review
. 1998 Nov;25(13):2021-7.

[New molecular prognostic markers in gastric carcinoma]

[Article in Japanese]
K Yoshida  1 , W Yasui, H Yokozaki, N Nishimoto, Y Kagawa, T Toge, E Tahara, T Yoshida, M Terada
Affiliations
  • PMID: 9838902
Review

[New molecular prognostic markers in gastric carcinoma]

[Article in Japanese]
K Yoshida et al. Gan To Kagaku Ryoho. 1998 Nov.

Abstract

Many molecular events have been reported as prognostic factors in gastric cancer. Amplifications of K-sam and c-met genes are often associated with poorly differentiated adenocarcinoma, while ERBB2 genes are amplified in well--differentiated adenocarcinomas of the stomach. Alterations of tumor suppressor regulators confer progression of gastric cancer. On the other hand, multi autocrine loops of growth factors/receptors in gastric cancer cells play a key role in the progression and metastasis of cancer cells. The overexpression of K-sam gene, occurs in 31.9% of gastric cancers, and the prognosis of patients with overexpression of K-sam gene is poorer than those without it. Multivariate analysis reveals that the overexpression of K-sam gene is an important factor for prognosis, lymphnode metastasis and the depth of tumor invasion of gastric carcinomas.

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