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Clinical Trial
. 1998 Nov;78(2):149-151.
doi: 10.1016/S0304-3959(98)00132-8.

The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study

J G McCleane  1 , M McLaughlin
Affiliations
Clinical Trial

The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study

J G McCleane et al. Pain. 1998 Nov.

Abstract

In a double blind, placebo controlled trial of 40 volunteers, the burning discomfort associated with application of capsaicin cream (0.025%) was compared to placebo, GTN cream (1.33%) and to the combination of capsaicin cream (0.025%) plus GTN cream 1.33%. Median VAS for burning pain were 0 for the placebo, GTN and GTN + capsaicin groups and 3 for the capsaicin group after single application of each cream at daily intervals. This study demonstrates that after single application the addition of GTN to capsaicin significantly reduces the burning discomfort associated with application of capsaicin alone.

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