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. 1976 Jul;10(1):25-7.
doi: 10.1128/AAC.10.1.25.

Pharmacokinetic parameters of sisomicin

B R Meyers, S Z Hirschman, S Yancovitz, B Ribner

Pharmacokinetic parameters of sisomicin

B R Meyers et al. Antimicrob Agents Chemother. 1976 Jul.

Abstract

Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 mug/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 mug/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters derived from the intramuscular and intravenous studies were quite similar.

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