Gentamicin- and cephalothin-associated rises in blood urea nitrogen
- PMID: 984759
- PMCID: PMC429692
- DOI: 10.1128/AAC.10.1.80
Gentamicin- and cephalothin-associated rises in blood urea nitrogen
Abstract
Standardized rates of drug-attributed rises in blood urea nitrogen were 8.6%, 2.9%, and 9.3%, respectively, in patients receiving gentamicin alone, cephalothin alone, and both drugs together. These results provide evidence against a substantial synergism between the two drugs in the production of impaired renal function.
Similar articles
-
Nephrotoxicity of combined cephalothin-gentamicin regimen.Arch Intern Med. 1975 Jun;135(6):850-2. Arch Intern Med. 1975. PMID: 1130930
-
Severe nephrotoxicity: a probable complication of cis-dichlorodiammineplatinum (II) and cephalothin-gentamicin therapy.Oncology. 1982;39(1):31-2. doi: 10.1159/000225600. Oncology. 1982. PMID: 7199128
-
Acute renal failure associated with combined gentamicin and cephalothin therapy.Br Med J. 1973 May 19;2(5863):396-7. doi: 10.1136/bmj.2.5863.396. Br Med J. 1973. PMID: 4703097 Free PMC article.
-
Prospective comparative evaluation of gentamicin or gentamicin plus cephalothin in the production of nephrotoxicity in man.J Antimicrob Chemother. 1979 Sep;5(5):581-90. doi: 10.1093/jac/5.5.581. J Antimicrob Chemother. 1979. PMID: 500516 Clinical Trial.
-
The use of synergistic combinations of antibiotics in patients with haematological diseases.Clin Haematol. 1976 Jun;5(2):361-77. Clin Haematol. 1976. PMID: 780029 Review. No abstract available.
Cited by
-
Evaluation of three antibiotic programs in newborn infants.Can Med Assoc J. 1978 Mar 18;118(6):659-62. Can Med Assoc J. 1978. PMID: 657058 Free PMC article. Clinical Trial.
-
Side effects of cephalosporins.Drugs. 1987;34 Suppl 2:105-20. doi: 10.2165/00003495-198700342-00009. Drugs. 1987. PMID: 3319495 Review.
-
Tobramycin nephrotoxicity: failure of cefotaxime to potentiate renal toxicity.Infection. 1982;10(4):233-9. doi: 10.1007/BF01666917. Infection. 1982. PMID: 6127319 Clinical Trial.
-
Effect of cefamandole nafate on the toxicity of tobramycin.Antimicrob Agents Chemother. 1977 Oct;12(4):465-9. doi: 10.1128/AAC.12.4.465. Antimicrob Agents Chemother. 1977. PMID: 921240 Free PMC article.
-
Drug interactions that matter. A critical reappraisal.Drugs. 1988 Jul;36(1):83-110. doi: 10.2165/00003495-198836010-00006. Drugs. 1988. PMID: 3063497 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources