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. 1976 Sep;10(3):571-2.
doi: 10.1128/AAC.10.3.571.

Antiviral effects of virazole in chronic hepatitis B surface antigen-seropositive chimpanzees

A E Denes, J W Ebert, K R Berquist, B L Murphy, J E Maynard

Antiviral effects of virazole in chronic hepatitis B surface antigen-seropositive chimpanzees

A E Denes et al. Antimicrob Agents Chemother. 1976 Sep.

Abstract

Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HB(s) Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.

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