Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Oct;10(4):630-8.
doi: 10.1128/AAC.10.4.630.

Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals

H R Sullivan, S L Due, D L Kau, J F Quay, W Miller

Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals

H R Sullivan et al. Antimicrob Agents Chemother. 1976 Oct.

Abstract

The metabolic fate of the orally effective cephalosporin antibiotic cefaclor (Lilly 99638) has been studied in rats, mice, and dogs. Cefaclor is efficiently absorbed from the gastrointestinal tract as the intact antibiotic. In rats and mice, cefaclor, for the most part, escapes metabolism in the body and is eliminated unchanged as unaltered antibiotic, primarily by renal excretion. In dogs, however, cefaclor is more labile to metabolism and only a portion of the administered antibiotic is eliminated unchanged via the kidney.

PubMed Disclaimer

References

    1. Biochem J. 1967 Mar;102(3):976-82 - PubMed
    1. Appl Microbiol. 1971 Oct;22(4):666-70 - PubMed
    1. J Med Chem. 1969 Mar;12(2):310-3 - PubMed
    1. J Antibiot (Tokyo). 1969 May;22(5):195-200 - PubMed
    1. Appl Microbiol. 1971 Oct;22(4):659-65 - PubMed

LinkOut - more resources