Comparative Study
doi: 10.1128/AAC.10.4.773.
Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin
- PMID: 984811
- PMCID: PMC429829
- DOI: 10.1128/AAC.10.4.773
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Comparative Study
Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin
Antimicrob Agents Chemother.
1976 Oct.
Abstract
The macrolide antibiotics josamycin and rosamicin were compared in vitro with erythromycin for activity against Staphylococcus aureus, S. epidermidis, and enterococci and with clindamycin for activity against a variety of anaerobic organisms. Rosamicin and erythromycin were similar in activity and superior to josamycin against aerobic cocci. Most isolates of S. aureus (96%), S. epidermidis (79%), and the enterococci (87%) were inhibited by 1.56 mug of either of the new macrolide compounds per ml. Clindamycin was the most active compound against the anaerobic organisms.
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