Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jun;51(3):155-9.
doi: 10.1136/mp.51.3.155.

Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: lack of association with Bcl-2 and p53 protein expression

M M Kennedy  1 , J J O'Leary, J L Oates, S B Lucas, D D Howells, S Picton, J O McGee
Affiliations

Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: lack of association with Bcl-2 and p53 protein expression

M M Kennedy et al. Mol Pathol. 1998 Jun.

Abstract

Aims: Human herpes virus 8 (HHV-8) is the infectious agent implicated in the pathogenesis of Kaposi's sarcoma, although its mode of action is unclear. Recent work indicates that the HHV-8 genome encodes a viral Bcl-2 homologue (v-Bcl-2). The aim of this study was to explore Bcl-2 expression in Kaposi's sarcoma using a unique set of HHV-8 positive and negative cases, and to determine whether there is a relation with p53 expression.

Methods: Up to 18 specimens from 17 patients were selected. HHV-8 status was determined using nested polymerase chain reaction (PCR) to the open reading frame (ORF) 26, with further confirmation by TaqMan PCR. In addition, Bcl-2 and p53 immunohistochemistry were performed using standard protocols.

Results: The results suggest that Bcl-2 and p53 expression is independent of HHV-8 status. In addition, there does not appear to be a direct correlation with disease stage.

Conclusions: HHV8 histopathogenesis is likely to be a multifactorial complex process, which may be mediated in part by viral genes and apoptosis regulating homologues.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7742-6 - PubMed
    1. J Virol. 1997 Jun;71(6):4187-92 - PubMed
    1. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8479-83 - PubMed
    1. Science. 1994 Dec 16;266(5192):1865-9 - PubMed
    1. Nature. 1995 Jan 5;373(6509):17-8 - PubMed

MeSH terms

Substances