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. 1998 Nov-Dec;42(6):1382-8.
doi: 10.1159/000332172.

Thyroid transcription factor-1 and cytokeratins 7 and 20 in pulmonary and breast carcinoma

H A Harlamert  1 , J Mira, P A Bejarano, R P Baughman, M A Miller, J A Whitsett, R Yassin
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Thyroid transcription factor-1 and cytokeratins 7 and 20 in pulmonary and breast carcinoma

H A Harlamert et al. Acta Cytol. 1998 Nov-Dec.

Abstract

Objective: To evaluate the immunohistochemical expression of a lung epithelial gene transcription factor, thyroid transcription factor-1 (TTF-1), in lung and breast carcinoma in pulmonary cytologic preparations and to correlate the results with the expression of cytokeratin 7 (CK7) and 20 (CK20).

Study design: Cell blocks of cytologic specimens were immunostained with antibodies to TTF-1, CK7 and CK20. Specimens included 41 primary lung carcinomas (21 adenocarcinomas, 8 squamous cell carcinomas and 12 small cell undifferentiated carcinomas) and 6 metastatic breast adenocarcinomas.

Results: The lung adenocarcinomas showed nuclear reactivity for TTF-1 in 76% (16/21) of the cases and a staining combination of CK7+/CK20- in 95% (20/21) of the cases. Only one case was CK7+/CK20+. All the breast carcinomas were nonreactive to TTF-1, and all were CK7+/CK20-. The squamous cell carcinomas and small cell undifferentiated carcinomas showed TTF-1 positivity in 38% (3/8) and 83% (10/12), respectively.

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