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. 1998 Nov;37(11):1188-92.
doi: 10.1093/rheumatology/37.11.1188.

Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis

H Ihn  1 , S Sato, M Fujimoto, K Takehara, K Tamaki
Affiliations

Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis

H Ihn et al. Br J Rheumatol. 1998 Nov.

Abstract

Objective: To determine the serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) in patients with systemic sclerosis (SSc).

Method: Serum samples from 80 patients with SSc and 20 healthy control subjects were examined by a sensitive enzyme-linked immunosorbent assay.

Results: The serum levels of sVCAM-1 and sE-selectin were significantly higher in the patients with SSc than in the healthy controls. The serum levels of sVCAM-1 were correlated with the presence of pulmonary fibrosis, joint involvement and elevated erythrocyte sedimentation rate levels. The serum levels of sE-selectin were correlated with the presence of pulmonary fibrosis.

Conclusion: These results suggest that endothelial activation is involved in the development of this disease.

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