Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Dec 11;282(5396):2082-5.
doi: 10.1126/science.282.5396.2082.

Proofreading and aminoacylation of tRNAs before export from the nucleus

E Lund  1 , J E Dahlberg
Affiliations

Proofreading and aminoacylation of tRNAs before export from the nucleus

E Lund et al. Science. .

Abstract

After synthesis and processing in the nucleus, mature transfer RNAs (tRNAs) are exported to the cytoplasm in a Ran.guanosine triphosphate-dependent manner. Export of defective or immature tRNAs is avoided by monitoring both structure and function of tRNAs in the nucleus, and only tRNAs with mature 5' and 3' ends are exported. All tRNAs examined can be aminoacylated in nuclei of Xenopus oocytes, thereby providing a possible mechanism for functional proofreading of newly made tRNAs. Inhibition of aminoacylation of a specific tRNA retards its appearance in the cytoplasm, indicating that nuclear aminoacylation promotes efficient export.

PubMed Disclaimer

Comment in

  • Nuclear functions charge ahead.
    Hopper AK. Hopper AK. Science. 1998 Dec 11;282(5396):2003-4. doi: 10.1126/science.282.5396.2003. Science. 1998. PMID: 9874653 No abstract available.

Publication types

MeSH terms

LinkOut - more resources