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Review
. 1998 Nov;23(11):429-33.
doi: 10.1016/s0968-0004(98)01278-x.

The structural and mechanochemical cycle of kinesin

E Mandelkow  1 , K A Johnson
Affiliations
Review

The structural and mechanochemical cycle of kinesin

E Mandelkow et al. Trends Biochem Sci. 1998 Nov.

Abstract

Kinesin is a microtubule-based motor protein that pulls vesicles or organelles towards the plus end of microtubules. Structural changes in the protein that drive motility are coupled to ATP binding and hydrolysis. Here, we attempt to integrate recent structural and kinetic results into a picture of the mechanochemical cycle of kinesin.

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