Review
doi: 10.1016/s0962-8924(98)01366-x.
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
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- PMID: 9854311
- DOI: 10.1016/s0962-8924(98)01366-x
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Review
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
Trends Cell Biol.
1998 Nov.
Abstract
Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology--signal transduction and membrane traffic. This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes.
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