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. 1976 Aug 15;158(2):505-7.
doi: 10.1042/bj1580505.

Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment

L M Jones, R H Michell

Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment

L M Jones et al. Biochem J. .

Abstract

Carbamoylcholine stimulated phosphatidylinositol breakdown in rat parotid-gland fragments incubated in either a Krebs--Ringer medium or an ion-depleted iso-osmotic sucrose medium. This suggest that phosphatidylinositol breakdown is not initiated by a change in the intracellular concentration of Na+ or of K+, and previous experiments have already indicated that it is independent of cyclic nucleotides and Ca2+. Thus it seems that this reaction may be initiated by a direct interaction at the plasma membrane between the activated muscarinic cholinergic receptor system and the enzyme that catalyses phosphatidylinositol breakdown.

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