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. 1998 Dec;51(6):1757-9.
doi: 10.1212/wnl.51.6.1757.

Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease

A Parsian  1 , B Racette, Z H Zhang, S Chakraverty, M Rundle, A Goate, J S Perlmutter
Affiliations

Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease

A Parsian et al. Neurology. 1998 Dec.

Abstract

A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample.

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