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Case Reports
. 1998 Nov-Dec;20(6):552-5.

Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11)

F Antillon  1 , F G Behm, S C Raimondi, S C Kaste, J T Sandlund, A S Pappo
Affiliations
  • PMID: 9856677
Case Reports

Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11)

F Antillon et al. J Pediatr Hematol Oncol. 1998 Nov-Dec.

Abstract

Purpose: A child with a primary lymphoma of bone (PLB) with a t(3;22)(q27;q11) is described.

Methods: An 11-year-old boy had a 5-week history of back pain and a destructive lesion of S1 that contained an epidural component. Histologic evaluation of a biopsy confirmed the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Karyotypic analysis disclosed a t(3;22)(q27;q11), but the amount of tumor tissue was insufficient for molecular studies of the BCL-6 gene.

Results: The patient remains free of disease 4 years after completion of intensive systemic chemotherapy and intrathecal chemotherapy.

Conclusions: The lymphoma in the patient described in this report is highly unusual because of the coexistence of pediatric PLB and a t(3;22)(q27q11).

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