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Review
. 1998 Dec;317(7174):1688-92.
doi: 10.1136/bmj.317.7174.1688.

1755 and all that: a historical primer of transmissible spongiform encephalopathy

P Brown  1 , R Bradley
Affiliations
Review

1755 and all that: a historical primer of transmissible spongiform encephalopathy

P Brown et al. BMJ. 1998 Dec.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The major players in the field of transmissible spongiform encephalopathy. (“The Young Bull” by Paulus Potter (1625-1654) in the Mauritshuis, The Hague, Netherlands)
Figure 2
Figure 2
Artist’s conception of the formation of abnormal PrP molecules, in which a normal molecule with three α-helices (red coils) and one β-sheet (yellow plate) (left panel) is configurationally altered by the proximity of an abnormal molecule with one α-helix and four β-sheets (right panel), leading to a cascade of molecular aggregation into visualisable deposits of amyloid in the brain. Exactly how this happens remains a mystery (Courtesy of WGBH/NOVA, Boston, and BBC/HORIZON, London)
Figure 3
Figure 3
Known and speculative interrelationships of transmissible spongiform encephalopathy in animals and humans
See this image and copyright information in PMC

References

    1. Journal of the House of Commons. 1755. p. 27. :87.
    1. Leopoldt JG. Nützliche und auf die Erfahrung Gegründete. Einleitung zu der landwirthschaft, fünf Theile. Berlin: Christian Friedrich Günthern,1759:348.
    1. Besnoit C, Morel C. Note sur les lésions nerveuses de la tremblante du mouton. Rev Vet. 1898;23:397–400.
    1. Besnoit C. La tremblante ou névrite périphérique enzootique du mouton. VI. Etiologie. Rev Vét. 1899;23:307–343.
    1. Cuillé J, Chelle P-L. La maladie dite “tremblante” du mouton; est-elle inoculable? Compte Rend Acad Sci. 1936;203:1552.