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Review
. 1998 Nov 26;223(1-2):9-20.
doi: 10.1016/s0378-1119(98)00369-2.

Recombinogenic targeting: a new approach to genomic analysis--a review

C S Shashikant  1 , J L Carr, J Bhargava, K L Bentley, F H Ruddle
Affiliations
Free article
Review

Recombinogenic targeting: a new approach to genomic analysis--a review

C S Shashikant et al. Gene. .
Free article

Abstract

Currently, recombinational cloning procedures based upon methods developed for yeast, Saccharomyces cerevisiae, are being exploited for targeted cloning and in-vivo modification of genomic clones. In this review, we will discuss the development of large-insert vectors, homologous recombination-based techniques for cloning and modification, and their application towards functional analysis of genes using transgenic mouse model systems.

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