doi: 10.1007/BF00498877.
Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment
- PMID: 986007
- DOI: 10.1007/BF00498877
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Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment
Naunyn Schmiedebergs Arch Pharmacol.
1976.
Abstract
the effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity.
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