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. 1999 Jan;44(1):2-5.
doi: 10.1136/gut.44.1.2.

Intestinal IgA: novel views on its function in the defence of the largest mucosal surface

J Mestecky  1 , M W Russell, C O Elson
Affiliations

Intestinal IgA: novel views on its function in the defence of the largest mucosal surface

J Mestecky et al. Gut. 1999 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Examples of interactions of epithelial cells with lymphocytes in mucosal defence. Viruses and bacteria which invade epithelial cells stimulate production of several pro- and anti-inflammatory cytokines; some of them (e.g. IL-6, IL-10, and TGFβ) participate in differentiation of arriving B cells into IgA producing plasma cells.3 Mucosal T cells of Th1 lineage which are abundant in the intestinal lamina propria produce, among other cytokines, IFN-γ which upregulates the expression of pIgR on epithelial cells, thus facilitating transepithelial transport of pIgA onto the luminal surface.7 S-IgA can interact with luminal antigens (Ag) and inhibit their absorption by epithelial cells (a). Antigens which escape such luminal exclusion (e.g. viruses)2425 encounter transported pIgA within the epithelial cells resulting in intracellular neutralisation (b). Antigens which penetrate the epithelial barrier interact with pIgA in the lamina propria and are eliminated as Ag-pIgA complexes by the pIgR dependent mechanism (c).25
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References

    1. Science. 1994 Nov 18;266(5188):1253-5 - PubMed
    1. Acta Paediatr Suppl. 1994;396:37-40 - PubMed
    1. J Leukoc Biol. 1995 Jun;57(6):875-82 - PubMed
    1. Clin Exp Immunol. 1996 Sep;105(3):537-43 - PubMed
    1. Semin Immunol. 1996 Feb;8(1):11-8 - PubMed

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