Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Dec;35(12):997-1003.
doi: 10.1136/jmg.35.12.997.

Linkage analysis in Rett syndrome families suggests that there may be a critical region at Xq28

T Webb  1 , A Clarke, F Hanefeld, J L Pereira, L Rosenbloom, C G Woods
Affiliations

Linkage analysis in Rett syndrome families suggests that there may be a critical region at Xq28

T Webb et al. J Med Genet. 1998 Dec.

Abstract

A whole X chromosome study of families in which Rett syndrome had been diagnosed in more than one member indicated that the region between Xq27 and Xqter was the most likely region to harbour a gene which may be involved in the aetiology of the disease. Further, more detailed studies of Xq28 detected weak linkage and a higher than expected sharing of maternally inherited alleles. It is suggested that there may be more than one gene involved in the aetiology of this syndrome, particularly as the very rare families in which more than one girl is affected often show variable clinical symptoms.

PubMed Disclaimer

References

    1. Science. 1992 Dec 11;258(5089):1784-7 - PubMed
    1. Nature. 1992 Oct 29;359(6398):794-801 - PubMed
    1. Nat Genet. 1993 Jan;3(1):49-55 - PubMed
    1. Hum Mol Genet. 1993 Sep;2(9):1503 - PubMed
    1. Am J Med Genet. 1993 Nov 15;47(7):1124-34 - PubMed