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. 1998 Apr 21;8(8):925-30.
doi: 10.1016/s0960-894x(98)00146-2.

Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation

A P Kozikowski  1 , G L Araldi, J Flippen-Anderson, C George, S Pshenichkin, E Surina, J Wroblewski
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Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation

A P Kozikowski et al. Bioorg Med Chem Lett. .
Free article

Abstract

A photochemical approach to the synthesis of the aminobicycloheptane 6a is reported. This compound assumes an extended glutamate conformation, and for this reason was created to further probe the structural features relevant to achieving selectivity for the subtypes of the metabotropic glutamate family of receptors.

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