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. 1998 Mar 17;8(6):687-90.
doi: 10.1016/s0960-894x(98)00098-5.

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

A K Ghosh  1 , J F Kincaid, W Cho, D E Walters, K Krishnan, K A Hussain, Y Koo, H Cho, C Rudall, L Holland, J Buthod
Affiliations

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

A K Ghosh et al. Bioorg Med Chem Lett. .

Abstract

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

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