doi: 10.1016/s0960-894x(98)00056-0.
New bronchodilators selected by molecular topology
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- PMID: 9871602
- DOI: 10.1016/s0960-894x(98)00056-0
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New bronchodilators selected by molecular topology
Bioorg Med Chem Lett.
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Abstract
Molecular topology has been applied to find new lead compounds with bronchodilator activity. Among the selected compounds stands out 3-(1H-tetrazol-5yl)-9H-thioxanthene-9 -one-10,10-dioxide, anthrarobin, 9-oxo-9H-thioxantene-3-carboxylic-10,10-dioxide acid, acenocoumarol and griseofulvin, with a percentage of relaxation, at 0.1 mM, of 91, 92, 85, 69, and 74%, respectively. Theophylline shows a correspondent value of 77% (Emax = 100% at 1 mM).
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