doi: 10.1016/s0960-894x(98)00069-9.
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1
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- PMID: 9871615
- DOI: 10.1016/s0960-894x(98)00069-9
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Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1
Bioorg Med Chem Lett.
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Abstract
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.
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