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. 1998 Jan 20;8(2):161-4.
doi: 10.1016/s0960-894x(97)10202-5.

Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III

G Baisch  1 , R Ohrlein, M Streiff
Affiliations

Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III

G Baisch et al. Bioorg Med Chem Lett. .

Abstract

Recombinant fucosyl-transferase-III (Lewis type enzyme) is used to prepare a series of non-natural sialyl-Lewis derivatives on a preparative scale. The enzyme tolerates a wide range of acceptors which have the natural N-acetyl group of the glucosamine moiety replaced by substituted aromatic and heteroaromatic amides.

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