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. 1998 Feb 17;8(4):333-8.
doi: 10.1016/s0960-894x(98)00029-8.

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

J Adams  1 , M Behnke, S Chen, A A Cruickshank, L R Dick, L Grenier, J M Klunder, Y T Ma, L Plamondon, R L Stein
Affiliations

Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

J Adams et al. Bioorg Med Chem Lett. .

Abstract

Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases.

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