Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Jun 2;8(11):1431-6.
doi: 10.1016/s0960-894x(98)00238-8.

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues

K J Barakat  1 , K Cheng, W W Chan, B S Butler, T M Jacks, K D Schleim, D F Hora Jr, G J Hickey, R G Smith, A A Patchett, R P Nargund
Affiliations

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues

K J Barakat et al. Bioorg Med Chem Lett. .

Abstract

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substituent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC50 = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.

PubMed Disclaimer

LinkOut - more resources