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. 1999 Jan 1;283(5398):83-7.
doi: 10.1126/science.283.5398.83.

The transcriptional program in the response of human fibroblasts to serum

V R Iyer  1 , M B Eisen, D T Ross, G Schuler, T Moore, J C Lee, J M Trent, L M Staudt, J Hudson Jr, M S Boguski, D Lashkari, D Shalon, D Botstein, P O Brown
Affiliations

The transcriptional program in the response of human fibroblasts to serum

V R Iyer et al. Science. .

Abstract

The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.

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Comment in

  • DNA chips give new view of classic test.
    Pennisi E. Pennisi E. Science. 1999 Jan 1;283(5398):17-8. doi: 10.1126/science.283.5398.17. Science. 1999. PMID: 9917256 No abstract available.
  • Wound healing.
    Hunt TK, Burke J, Barbul A, Gimbel ML. Hunt TK, et al. Science. 1999 Jun 11;284(5421):1775. doi: 10.1126/science.284.5421.1773d. Science. 1999. PMID: 10391796 No abstract available.

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