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. 1998 Jul 7;8(13):1703-6.
doi: 10.1016/s0960-894x(98)00298-4.

Ascorbic acid-based inhibitors of alpha-amylases

A D Abell  1 , M J Ratcliffe, J Gerrard
Affiliations

Ascorbic acid-based inhibitors of alpha-amylases

A D Abell et al. Bioorg Med Chem Lett. .

Abstract

A series of ascorbic acid and isoascorbic acid derivatives has been evaluated as inhibitors of malt, bacterial, fungal, pancreatic and salivary alpha-amylases using a simple and quick assay procedure. The results demonstrate that the enediol moiety of ascorbic acid is essential for alpha-amylase inhibition. Acylation of the primary and secondary alcohols, and the absolute configuration of the secondary alcohol, do not affect the potency of inhibition.

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